Brain Disorders

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Our brains shape everything about us—our memories, emotions, personalities, and the way our bodies function. Yet over 600 known brain disorders affect one in six people, disrupting not only our physical health but also our sense of self.

Because of the brain’s complexity, neurological disorders remain among the most challenging conditions to predict, diagnose, and treat. Progress demands bold investment in cutting-edge neuroscience and a clear path to deliver breakthroughs to the people who need them.

Science Philanthropy Accelerator for Research and Collaboration (SPARC) partners with funders to target high-impact opportunities where philanthropy can accelerate progress in brain health. We break through research roadblocks, bridge gaps across disciplines, and catalyze innovation in diagnostics and treatment—paving the way toward a future where better brain health is within reach for all.

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Active Funding Programs

Breakthrough Research in ALS

SPARC partnered with Tambourine PhilanthropiesTambourine ALS Breakthrough Research Fund to support innovative early stage research into amyotrophic lateral sclerosis (ALS) through the ALS Breakthrough Research Fund.

Programmatic Areas

Amyotrophic Lateral Sclerosis

ALS is a fatal motor neuron disease that causes progressive paralysis and has no known cure. SPARC has developed, refined, and implemented philanthropic strategies for organizations dedicated to ALS research and care.

Frontotemporal Dementia (FTD)

FTD is a progressive neurodegenerative disease that impairs behavior, language, and movement. SPARC has worked with several partners to develop FTD-focused strategies from developing new therapies and diagnostics to expanding the basic understanding of the disease.

Innovative Solutions for Brain Health

The rising prevalence of neurodegenerative diseases and mental health challenges calls for efforts to reduce disparities in care and to strengthen strategies for prevention, early intervention, and long-term support. SPARC developed philanthropic approaches that drive progress in neurotechnology, artificial intelligence, and community-based interventions to improve brain health.

Alzheimer’s Disease

Alzheimer’s disease is the most common form of dementia, causing drastic changes in cognition, memory, and behavior. SPARC has developed philanthropic strategies for organizations focused on Alzheimer’s, ranging from research-focused fellowship programs to pillars of care.

Parkinson’s Disease

Parkinson’s disease is a progressive neurological disorder that is known for causing difficulties with movement, but it can also affect mood and sleep. SPARC developed key strategies for and then launched Aligning Science Across Parkinson’s (ASAP), a consortium working to improve scientific understanding of the disease.

Epilepsy

Epilepsy is a neurological condition in which brain cells signal improperly, triggering seizures. SPARC has developed a suite of philanthropic opportunities to support researchers and patients in these spaces.

Childhood Brain Cancer

Childhood brain cancer is the leading cause of cancer-related death in children and adolescents, comprising over 16 percent of pediatric cancer diagnoses and encompassing over 100 rare and complex tumor subtypes. SPARC has partnered with leading institutions and a dedicated anonymous donor to support an integrated, global program that spans molecular research, therapeutic development, and cross-sector collaboration to accelerate innovation, address systemic funding gaps, and improve outcomes for affected children and their families.

Glioblastoma

Glioblastoma multiforme is the most aggressive and deadly form of brain cancer, with limited treatment options and a median survival rate of just over one year. SPARC has driven progress by identifying strategic funding opportunities and opportunities to advance clinical trial innovation and by accelerating research aimed at improving outcomes.

Neurodevelopmental Disorders

CAMK2-related neurodevelopmental disorders cause intellectual disability, delayed development and motor skills, and behavioral abnormalities, with no treatments beyond symptom management. SPARC is developing philanthropic strategies to support researchers in the discovery and development of CAMK2 therapeutics.

Program Experts

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Cara Altimus, PhD

Managing Director

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Sylvie Raver, PhD

Senior Director

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Quinton Banks, PhD

Associate Director

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Emily Baxi, PhD

Director

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Lillian Parr

Associate

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Nadia Sarfraz, PhD

Senior Associate

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Samantha Schumm, PhD

Associate Director

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Aggie Stephens, MSc

Associate Director

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