Baszucki Brain Research Fund’s Bipolar Disorder Grant Program

In 2021, SPARC partnered with the Baszucki Group to co-develop the Baszucki Brain Research Fund’s Bipolar Disorder Grant program. This initiative was designed to support BD research at the point of treatment, a critical yet historically underfunded area. A total of $9.2 million in funding was awarded to 45 investigators across 35 organizations globally. Each recipient received up to $200,000 over two years to support pilot research focused on therapeutic discovery and translational efforts, aiming to accelerate progress in the field.

SPARC led the full lifecycle of the grant program, from proposal solicitation and peer review to award distribution and post-award reporting. To further support the research community, we organized and hosted the Catalyzing New Research in Bipolar Disorder Meeting in Denver, CO, in 2022. This convening brought together over 70 investigators alongside a community of BD funders from private foundations, nonprofits, and government agencies. Attendees engaged in peer feedback, explored new collaborations, and connected directly with funding partners.

Awardees and Their Projects

Project

Oxygenating the brain with laser stimulation therapy to improve cognitive function in bipolar disorder

Jorge Almeida, MD, PhD University of Texas at Austin

Project

Energy metabolism and bipolar disorder: from early detection to diagnosis and effective treatment

Ana Andreazza, PhD University of Toronto

Project

Using human brain organoids to understand the biology of response to lithium treatment

Paola Arlotta, PhD Harvard University

Project

Mood Stabilizer Genomics (MoStGen) Consortium: A study of anticonvulsant mood stabilizer (AMS) pharmacogenomics

Joanna Biernacka, PhD Mayo Clinic

Project

A novel mitochondrial target as a therapeutic approach for bipolar disorder

Hilary Blumberg, PhD Yale School of Medicine

Project

Using microglia-like cells to identify potential responders to L-type channel blockers

Amanda Brown, PhD Johns Hopkins University

Project

Identifying modifiable risk factors for poor outcome in bipolar disorder: therapeutic mechanistic targets

Katherine Burdick, PhD Brigham and Women’s Hospital

Project

Transcranial photobiomodulation with near-infrared light for impulsivity in hypomania

Paolo Cassano, MD, PhD Massachusetts General Hospital

Project

Affective disorders, seasonal photoperiod, and adaptive neurotransmitter plasticity in a subtype of mouse median raphe serotonergic neuron

Susan Dymecki, MD, PhD Harvard Medical School

Project

A randomized control trial of the effectiveness of blue-blocking glasses for mania in inpatients with bipolar disorder

Jess Fiedorowicz, PhD The Ottawa Hospital

Project

Proof of concept study for intranasal delivery of MANF as a novel treatment approach for bipolar disorder

Benicio Frey, MD McMaster University

Project

Targeting accelerated aging in bipolar disorder: calorie restriction mimetics as a novel treatment strategy

Gabriel Fries, PhD University of Texas

Project

Community-based transcranial direct current stimulation treatment for bipolar depression

Cynthia Fu, PhD University of East London

Project

Effects of lithium on mesolimbic dysfunction in bipolar mania

Todd Gould, MD University of Maryland School of Medicine

Project

Bipolar efficacy biomarkers for accelerated intermittent theta burst rTMS trial

Itay Hadas, PhD University of California, San Diego

Project

Identifying digital biomarkers of illNess activity and Treatment REsPonse In Bipolar Disorder (INTREPIBD)

Diego Hidalgo-Mazzei, MD, PhD University of Barcelona

Project

The contribution of the gut to bipolar disorder

Damien Keating, PhD Flinders University of South Australia

Project

A randomized, double-blind, placebo-controlled study of probiotics as adjuvant therapy for bipolar depression: a proof-of-concept trial

Beny Lafer, PhD University of São Paulo Medical School

Project

Causal lesion network guided treatment of bipolar mania with transcranial electrical stimulation

Paulo Lizano, MD Beth Isreal Deaconess Medical Center

Project

A randomized placebo-controlled trial of the fatty acid amide hydrolase inhibitor palmitoylethanolamide in bipolar depression

Rodrigo Machado-Vieira, MD, PhD University of Texas

Project

Brain insulin sensitivity and reward behavior in bipolar disorder

Rodrigo Mansur, PhD University Health Network

Project

DNA methylation markers in redicting response to lithium therapy in bipolar disorder (MeRLiT)

Cynthia Marie-Claire, PhD University of Paris

Project

Identification of therapeutic targets for the treatment of bipolar disorder

Colleen McClung, PhD University of Pittsburgh

Project

A collaborative treatment network for youth with or at high risk for bipolar disorder

David Miklowitz, PhD University of California, Los Angeles

Project

Investigation of a polymorphic DNA repeat at the CACNA1C gene in bipolar disorder

Ricardo Mouro Pinto, PhD Massachusetts General Hospital

Project

Statistical and functional fine mapping of bipolar disorder genetic risk loci

Niamh Mullins, PhD Icahn School of Medicine at Mount Sinai

Project

Xenon for Bipolar Depression

Andrew Nierenberg, MD Massachusetts General Hospital

Project

Targeting exosome cargos in bipolar disorder

Sue O’Shea, PhD University of Michigan

Project

CACNA1C Genotype: Correlation with brain and blood levels of CACNA1C and treatment responsiveness

Harry Pantazopoulos, PhD University of Mississippi Medical Center

Project

Novel application of VNS therapy in the treatment of juvenile bipolar disorder

Demitri Papolos, MD Juvenile Bipolar Research Foundation

Project

Cerebellar stimulation as a novel therapy for bipolar disorder

Krystal Parker, PhD University of Iowa

Project

Establishing the effect of electroencephalography (EEG)-guided theta burst stimulation on reducing mania/hypomania-related affect and reward-driven behavior in bipolar disorder

Mary Phillips, MD University of Pittsburgh

Project

Experimentally evaluating the hypothesized mechanism of action of N-acetylcysteine for bipolar disorder

James Prisciandaro, PhD Medical University of South Carolina

Project

Novel metabolic signatures in patients with bipolar disorder: toward a specialized treatment paradigm

Natalie Rasgon, MD, PhD Stanford University School of Medicine

Project

Temporospatial lithium central nervous system kinetics in bipolar disorder using repeated 7Li-MRI brain imaging

Philipp Ritter, PhD Technische Universität, Dresden

Project

The efficacy of adjunctive intranasal insulin for the treatment of neurocognitive dysfunction in bipolar disorder: A 12-week double-blind randomized placebo-controlled clinical trial

Susan Rossell, PhD Swinburne University of Technology

Project

Uncovering the genetic programs and brain circuits that mediate mania

Bernardo Sabatini, MD, PhD Harvard Medical School

Project

The Behavioral Health AVATAR (BHA) for automatic nonverbal behavioral analysis for personalizing treatment of bipolar disorder

Kirti Saxena, MD Baylor College of Medicine

Project

Intensive TMS for rapid relief of bipolar depression symptoms

Yvette Sheline, MD University of Pennsylvania School of Medicine

Project

Developing brain imaging analysis expertise for personalizing transcranial electric stimulation in anhedonia treatment of patients with bipolar depression

Jair Soares, MD, PhD University of Texas

Project

The ENIGMA bipolar medication Initiative: a global study of bipolar disorder medication effects on the brain

Paul Thompson, PhD University of Southern California

Project

Enhancing neural synchrony and affective cognitive control in bipolar disorder using personalized transcranial alternating current stimulation (tACS)

Ivy Tso, PhD University of Michigan

Project

Repurposing drugs to treat bipolar depression using stem cell technology

Ken Walder, PhD Deakin University

Project

Transcriptomic and functional characterization of cerebral organoids in pediatric bipolar disorder

Janet Wozniak, MD Massachusetts General Hospital

Project

Leveraging a collaborative network to test n Novel iTBS treatment for bipolar depression

Peter Zandi, PhD Johns Hopkins University