Baszucki Brain Research Fund’s Bipolar Disorder Grant Program
In 2021, SPARC partnered with the Baszucki Group to co-develop the Baszucki Brain Research Fund’s Bipolar Disorder Grant program. This initiative was designed to support BD research at the point of treatment, a critical yet historically underfunded area. A total of $9.2 million in funding was awarded to 45 investigators across 35 organizations globally. Each recipient received up to $200,000 over two years to support pilot research focused on therapeutic discovery and translational efforts, aiming to accelerate progress in the field.
SPARC led the full lifecycle of the grant program, from proposal solicitation and peer review to award distribution and post-award reporting. To further support the research community, we organized and hosted the Catalyzing New Research in Bipolar Disorder Meeting in Denver, CO, in 2022. This convening brought together over 70 investigators alongside a community of BD funders from private foundations, nonprofits, and government agencies. Attendees engaged in peer feedback, explored new collaborations, and connected directly with funding partners.
Awardees and Their Projects
Oxygenating the brain with laser stimulation therapy to improve cognitive function in bipolar disorder
Jorge Almeida, MD, PhD University of Texas at Austin
Energy metabolism and bipolar disorder: from early detection to diagnosis and effective treatment
Ana Andreazza, PhD University of Toronto
Using human brain organoids to understand the biology of response to lithium treatment
Paola Arlotta, PhD Harvard University
Mood Stabilizer Genomics (MoStGen) Consortium: A study of anticonvulsant mood stabilizer (AMS) pharmacogenomics
Joanna Biernacka, PhD Mayo Clinic
A novel mitochondrial target as a therapeutic approach for bipolar disorder
Hilary Blumberg, PhD Yale School of Medicine
Using microglia-like cells to identify potential responders to L-type channel blockers
Amanda Brown, PhD Johns Hopkins University
Identifying modifiable risk factors for poor outcome in bipolar disorder: therapeutic mechanistic targets
Katherine Burdick, PhD Brigham and Women’s Hospital
Transcranial photobiomodulation with near-infrared light for impulsivity in hypomania
Paolo Cassano, MD, PhD Massachusetts General Hospital
Affective disorders, seasonal photoperiod, and adaptive neurotransmitter plasticity in a subtype of mouse median raphe serotonergic neuron
Susan Dymecki, MD, PhD Harvard Medical School
A randomized control trial of the effectiveness of blue-blocking glasses for mania in inpatients with bipolar disorder
Jess Fiedorowicz, PhD The Ottawa Hospital
Proof of concept study for intranasal delivery of MANF as a novel treatment approach for bipolar disorder
Benicio Frey, MD McMaster University
Targeting accelerated aging in bipolar disorder: calorie restriction mimetics as a novel treatment strategy
Gabriel Fries, PhD University of Texas
Community-based transcranial direct current stimulation treatment for bipolar depression
Cynthia Fu, PhD University of East London
Effects of lithium on mesolimbic dysfunction in bipolar mania
Todd Gould, MD University of Maryland School of Medicine
Bipolar efficacy biomarkers for accelerated intermittent theta burst rTMS trial
Itay Hadas, PhD University of California, San Diego
Identifying digital biomarkers of illNess activity and Treatment REsPonse In Bipolar Disorder (INTREPIBD)
Diego Hidalgo-Mazzei, MD, PhD University of Barcelona
The contribution of the gut to bipolar disorder
Damien Keating, PhD Flinders University of South Australia
A randomized, double-blind, placebo-controlled study of probiotics as adjuvant therapy for bipolar depression: a proof-of-concept trial
Beny Lafer, PhD University of São Paulo Medical School
Causal lesion network guided treatment of bipolar mania with transcranial electrical stimulation
Paulo Lizano, MD Beth Isreal Deaconess Medical Center
A randomized placebo-controlled trial of the fatty acid amide hydrolase inhibitor palmitoylethanolamide in bipolar depression
Rodrigo Machado-Vieira, MD, PhD University of Texas
Brain insulin sensitivity and reward behavior in bipolar disorder
Rodrigo Mansur, PhD University Health Network
DNA methylation markers in redicting response to lithium therapy in bipolar disorder (MeRLiT)
Cynthia Marie-Claire, PhD University of Paris
Identification of therapeutic targets for the treatment of bipolar disorder
Colleen McClung, PhD University of Pittsburgh
A collaborative treatment network for youth with or at high risk for bipolar disorder
David Miklowitz, PhD University of California, Los Angeles
Investigation of a polymorphic DNA repeat at the CACNA1C gene in bipolar disorder
Ricardo Mouro Pinto, PhD Massachusetts General Hospital
Statistical and functional fine mapping of bipolar disorder genetic risk loci
Niamh Mullins, PhD Icahn School of Medicine at Mount Sinai
Xenon for Bipolar Depression
Andrew Nierenberg, MD Massachusetts General Hospital
Targeting exosome cargos in bipolar disorder
Sue O’Shea, PhD University of Michigan
CACNA1C Genotype: Correlation with brain and blood levels of CACNA1C and treatment responsiveness
Harry Pantazopoulos, PhD University of Mississippi Medical Center
Novel application of VNS therapy in the treatment of juvenile bipolar disorder
Demitri Papolos, MD Juvenile Bipolar Research Foundation
Cerebellar stimulation as a novel therapy for bipolar disorder
Krystal Parker, PhD University of Iowa
Establishing the effect of electroencephalography (EEG)-guided theta burst stimulation on reducing mania/hypomania-related affect and reward-driven behavior in bipolar disorder
Mary Phillips, MD University of Pittsburgh
Experimentally evaluating the hypothesized mechanism of action of N-acetylcysteine for bipolar disorder
James Prisciandaro, PhD Medical University of South Carolina
Novel metabolic signatures in patients with bipolar disorder: toward a specialized treatment paradigm
Natalie Rasgon, MD, PhD Stanford University School of Medicine
Temporospatial lithium central nervous system kinetics in bipolar disorder using repeated 7Li-MRI brain imaging
Philipp Ritter, PhD Technische Universität, Dresden
The efficacy of adjunctive intranasal insulin for the treatment of neurocognitive dysfunction in bipolar disorder: A 12-week double-blind randomized placebo-controlled clinical trial
Susan Rossell, PhD Swinburne University of Technology
Uncovering the genetic programs and brain circuits that mediate mania
Bernardo Sabatini, MD, PhD Harvard Medical School
The Behavioral Health AVATAR (BHA) for automatic nonverbal behavioral analysis for personalizing treatment of bipolar disorder
Kirti Saxena, MD Baylor College of Medicine
Intensive TMS for rapid relief of bipolar depression symptoms
Yvette Sheline, MD University of Pennsylvania School of Medicine
Developing brain imaging analysis expertise for personalizing transcranial electric stimulation in anhedonia treatment of patients with bipolar depression
Jair Soares, MD, PhD University of Texas
The ENIGMA bipolar medication Initiative: a global study of bipolar disorder medication effects on the brain
Paul Thompson, PhD University of Southern California
Enhancing neural synchrony and affective cognitive control in bipolar disorder using personalized transcranial alternating current stimulation (tACS)
Ivy Tso, PhD University of Michigan
Repurposing drugs to treat bipolar depression using stem cell technology
Ken Walder, PhD Deakin University
Transcriptomic and functional characterization of cerebral organoids in pediatric bipolar disorder
Janet Wozniak, MD Massachusetts General Hospital
Leveraging a collaborative network to test n Novel iTBS treatment for bipolar depression
Peter Zandi, PhD Johns Hopkins University
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