Grants

Transcriptomic Signatures of Sarcoidosis-Associated Pulmonary Fibrosis

Sarcoidosis of the lungs, or pulmonary sarcoidosis, can lead to fibrosis and respiratory failure for only some of the people with the diagnosis. Aiming to identify who is at risk for more severe outcomes, this research will compare changes in RNA transcription between blood samples–both within a group of people with sarcoidosis-associated pulmonary fibrosis (SAPF), and between SAPF versus non-progressing or non-fibrotic cases. Principal investigator: Mary Richert, MD; National Jewish Health

Environmental Drivers of Clinical Heterogeneity in Pulmonary Sarcoidosis

This research aims to assess the association between exposures to airborne risk factors and patient outcomes in sarcoidosis of the lungs, or pulmonary sarcoidosis. , overlaying HLA genotypes for additional context, by evaluating 75 subjects for six months. Principal investigator: Kristen Mathias, MD; Johns Hopkins University

Prognostic and Mechanistic Metabolomic Drivers of Sarcoidosis Progression​

By assessing a 350+ person group of people with sarcoidosis over two years, this research will measure differences in metabolite changes between people whose sarcoidosis resolves versus those whose sarcoidosis progresses, and will seek to identify blood biomarkers that predict sarcoidosis prognosis. Principal investigator: Bing Ma, PhD; University of Maryland, Baltimore

Uncovering the TDP-43 aggregate proteome and its role in FTLD pathogenesis

This research project seeks to determine and compare the molecular composition of diverse TDP-43 aggregates in FTLD-TDP brain tissue by using an innovative microscopy-guided proteomics approach and investigate the contribution of the identified TDP-43-associated proteins to the disease process in advanced tissue culture models of FTLD-TDP. Principal Investigator Wilfried Rossoll, PhD Mayo Clinic

Psychometric assessment of misophonia: a validation study of measurement tools for the severity of the disorder

Validation of a Misophonia Screener in Pediatric Primary Care

Acceptance and Commitment Therapy (ACT) plus Behavioral Intervention for Misophonia

Characterizing how the experience of Misophoniais shaped by environmental and internal states

Effects of Hearing, Seeing and Imagining Misophonia Triggers: An fMRI Investigation

The Balance Between Top-Down and Bottom-Up Attention in Misophonia versus ASD

Role of Expectations and Beliefs in Driving Brain Activity in Misophonia

A Transdiagnostic Investigation of Decreased Sound Tolerance in Adult