| Author: Kirstie Keller, PhD; LaTese Briggs, PhD; and Ekemini Riley, PhD

Alzheimer’s Disease: A Giving Smarter Guide

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Brain Disorders Alzheimer’s Disease

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, affecting over 6 million Americans. AD patients experience declining cognitive function and eventually require full-time care. There is no cure for AD, making it a painful diagnosis for patients and their families.

In 2018, SPARC partnered with the Shanahan Family Foundation to conduct a landscape assessment of AD research and funding patterns, culminating in the development of a Giving Smarter Guide. This report lays out key opportunities for philanthropists to fund high-impact research, including:

  • Standardizing, validating, and identifying new biomarkers for AD
  • Improving preclinical models of AD to reduce clinical trial failures
  • Identifying new therapeutic targets beyond amyloid beta
  • Reducing silos in AD research that lead to inefficiencies and knowledge gaps

By filling current gaps in research, philanthropic capital has the potential to make a transformative impact in addressing this devastating disease.