Grants

https://sciencephilanthropy.org/wp-content/uploads/2025/10/Grants_1920x480_BW.webp

SPARC’s work with several of our partners includes implementing grant programs that fund biomedical research.

Explore each grant program’s funded research below.

2025 Frontotemporal dementia (FTD)

The role of ANXA11 in FTLD-TDP

This research investigates the role of the protein annexin 11 (ANXA11), which appears to clump together with the well-known disease protein TDP-43 in brain cells. The study aims to determine how frequently aberrant ANXA11 occurs in FTD patients and whether it correlates with symptoms, as well as to understand how ANXA11 and TDP-43 work together to damage the brain.

2025 Frontotemporal dementia (FTD)

Developing a Misfolded TDP-43 Molecular Degrader

This project develops novel therapeutic compounds that specifically target and degrade aggregated TDP-43 protein in frontotemporal dementia. The approach aims to clear toxic TDP-43 aggregates from the cell cytoplasm and restore normal TDP-43 function in the nucleus, potentially providing a targeted treatment for the 50% of FTD cases driven by TDP-43 pathology.

11 of 11
1 … 8 9 10 11